Efficacy of Purified Vi Polysaccharide Typhoid Vaccine
نویسندگان
چکیده
منابع مشابه
Efficacy of purified Vi polysaccharide typhoid vaccine.
This experiment was conducted to assess the efficacy of typhoid vaccine newly produced by purifying Vi antigen of Salmonella typhi. With Karber method, LD50 of challenging organism (S. typhi ty2) was determined as 6.31 CFU/mouse, and then the organism was used for the study. With Probits method, ED50 of the vaccine was determined as 0.016 microg / 0.5 ml / mouse. The ELISA titer (0.5097+/-0.060...
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OBJECTIVE To test the efficacy of locally produced Vi vaccine over a time period of longer than one year. METHODS A double-blinded, randomized field trial was performed in Guangxi Zhuang Autonomous Region in south-western China, using 30 micrograms doses of locally produced Vi. Enrolled subjects were 3-50 years of age, although the majority (92%) were school-aged children, who have the highes...
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Salmonella Typhi, first isolated in 1884, results in infection of the intestines and can end in death and disability. Due to serious adverse events post vaccination, whole cell killed vaccines have been replaced with new generation vaccines. The efficacy of Vi polysaccharide (ViPS) vaccine, a new generation, single-dose intramuscular typhoid vaccine was assessed in Nepal in 1987. However, despi...
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ژورنال
عنوان ژورنال: Journal of Veterinary Science
سال: 2002
ISSN: 1229-845X
DOI: 10.4142/jvs.2002.3.2.67